I know the CentOS 5 is EOL and is not releasing any Security Updates at this time. But want to check if this particular vulnerability in Exim which causes Remote Code Execution and Buffer Overflow vulnerability, Is there any patches available to install.
Support for security such as Firewalls and securing linux
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It is affected, see this statement. I don't know if anyone has made a fixed version available, but it won't come via RHEL/CentOS. You may need to roll your own patch, or preferably, migrate your mail server to CentOS 6 or 7.