I have a virtual Server CentOS 7.3.1611 with kernel 3.10.0-514.26.2.el7.x86_64 on a ESXi 6.5 and have two network adapters (vmxnet3) added.
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ens160: flags=4163<UP,BROADCAST,RUNNING,MULTICAST> mtu 1500
inet 192.168.100.70 netmask 255.255.255.0 broadcast 192.168.100.255
ether 00:50:56:af:50:a7 txqueuelen 1000 (Ethernet)
RX packets 18615 bytes 1857570 (1.7 MiB)
RX errors 0 dropped 15 overruns 0 frame 0
TX packets 17888 bytes 2061646 (1.9 MiB)
TX errors 0 dropped 0 overruns 0 carrier 0 collisions 0
ens192: flags=4163<UP,BROADCAST,RUNNING,MULTICAST> mtu 1500
inet 192.168.113.2 netmask 255.255.255.0 broadcast 192.168.113.255
ether 00:50:56:af:47:70 txqueuelen 1000 (Ethernet)
RX packets 1330 bytes 116802 (114.0 KiB)
RX errors 0 dropped 9 overruns 0 frame 0
TX packets 1251 bytes 116606 (113.8 KiB)
TX errors 0 dropped 0 overruns 0 carrier 0 collisions 0
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BOOTPROTO=static
DEVICE=ens160
HWADDR=00:50:56:af:50:a7
ONBOOT=yes
IPADDR=192.168.100.70
NETMASK=255.255.255.0
GATEWAY=192.168.100.1
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DEVICE=ens192
BOOTPROTO=static
HWADDR=00:50:56:af:47:70
ONBOOT=yes
IPADDR=192.168.113.2
NETMASK=255.255.255.0
GATEWAY=192.168.113.1
route -n:
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Destination Gateway Genmask Flags Metric Ref Use Iface
0.0.0.0 192.168.100.1 0.0.0.0 UG 100 0 0 ens160
0.0.0.0 192.168.113.1 0.0.0.0 UG 101 0 0 ens192
192.168.100.0 0.0.0.0 255.255.255.0 U 100 0 0 ens160
192.168.113.0 0.0.0.0 255.255.255.0 U 100 0 0 ens192
ARP table on client:
gateway ether 00:10:f3:5e:7f:6b C ens160
gateway ether 00:10:f3:5e:7f:6b C ens192
So the problem is, if I try a ping 192.168.100.1 I have 0% packet loss, but if i try to ping 192.168.113.1 I have 4-10 pings in a row of success, than I have a long timeout, that some pings are succesfully again. I have a packet loss of ~75% percent.
I temporary removed GATEWAY entry of ens192 and restarted network and adapters (ifdown && ifup) but it is the same problem.